A Message from Dr. Liu
“AISPIRE MD was developed by a board-certified dermatologist for patients who deserve better than what the market currently offers. After 28 years in practice and over 21,000 patients, I could not find topical products that matched what I knew the published science was capable of delivering. So I spent three years developing them myself—at clinical concentrations, with liposomal delivery, and with a formulation partner who shares my commitment to evidence-based outcomes. If you share that commitment, I’d welcome a conversation.”
— Dr. Grace Liu, MD | Board-Certified Dermatologist | Mohs Surgeon | Fellow, AAD
What Makes AISPIRE MD Formulatorially Unique
2% Wild Salmon PDRN — Why Concentration Is Everything
Most PDRN skincare products contain between 0.1% and 0.5%, or they use plant-derived PDRN, which lacks the peer-reviewed evidence base of salmon-derived PDRN. The DNA Moisturizer contains 2% (20,000 PPM)—the highest clinical concentration available in any topical cream in the world.
Concentration is directly linked to A2A receptor activation, fibroblast proliferation, and measurable collagen synthesis. At 2%, documented outcomes include:
- Up to 30% increase in fibroblast proliferation
- 35% increase in collagen synthesis over 8–12 weeks
- 45% improvement in hydration after 4 weeks
Seven-Active Brightening System — The Multi-Pathway Rationale
Hyperpigmentation is produced through multiple simultaneous biological pathways. Products that block only one pathway fail the majority of patients. The Luminous Serum addresses every known pathway of melanin overproduction at the same time, using seven synergistic actives including 2MNG—a novel melanogenesis inhibitor currently found in no other serum on the market.
The triple-blockade of Tranexamic Acid, Cysteamine, and Glutathione alone addresses pigmentation at three entirely distinct molecular levels—the same approach clinical medicine uses for complex conditions.
Pharmaceutical-Grade Liposomal Delivery
Topical bioavailability is the central limitation of most skincare products. Liposomal delivery is not a marketing claim—it is a pharmaceutical-grade technology borrowed from drug delivery science and applied to cosmeceutical formulation. Every product in the AISPIRE MD line uses phospholipid bilayer encapsulation to achieve epidermal
and dermal penetration at concentrations that standard topical application cannot reach.
Clinical Evidence Summary
Key actives, mechanisms, and selected published references for physician review.
| Active Ingredient | Primary Mechanism | Clinical Endpoint | Key Reference |
|---|---|---|---|
| Salmon PDRN (2%) | A2A receptor activation; fibroblast proliferation; collagen synthesis | 5% collagen increase / 45% hydration improvement (8–12 wks) | Journal of Skin and Stem Cell, 2025; Annals of Dermatology, 2016 |
| Tranexamic Acid | Plasminogen–keratinocyte binding inhibition; anti-inflammatory; antiangiogenic | Significant reduction in MASI; comparable/superior to hydroquinone | AlJabr et al., J Cosmet Dermatol 2026 (DOI: 10.1111/jocd.70692) |
| Cysteamine | Dopachrome inhibition; glutathione elevation; copper chelation | 38–58% mMASI decrease at 120 days (p = 0.002) | MDPI J Clin Med meta-analysis, Dec 2024 (8 RCTs) |
| Bakuchiol | Retinol-equivalent gene expression (collagen I, III, IV upregulation) | Equivalent wrinkle surface area reduction to 0.5% retinol; no adverse effects | Dhaliwal et al., Br J Dermatol, 2019 |
| Vitamin C (Liposomal) | Collagen cofactor (prolyl/lysyl hydroxylase); tyrosinase inhibition; ROS neutralization | 4× higher bioavailability vs. free ascorbic acid; increased epidermal thickness | Scientific Reports (Nature) 2020; J Liposome Research 2025 |
| Centella Asiatica | TGF-β/Smad collagen anabolism; NF-κB attenuation; ceramide synthesis | Statistically significant barrier function, wound healing, and inflammation improvements | Pharmacia 2025 review; J Dermatol Treatment meta-analysis 2015 |
| 2MNG | Pre-pigment melanin precursor binding; eumelanin and pheomelanin synthesis inhibition | Pigmentation reduction in as early as 2 weeks; melanocyte integrity preserved | PNovel ingredient; currently found in no other serum on the market |
| Liposomal Delivery | Phospholipid bilayer membrane-mimicry; lipid exchange with stratum corneum | Up to 4× increased bioavailability; deeper epidermal and dermal penetration | J Liposome Research 2025; PMC/NIH liposomal ascorbic acid study |
Professional Account Information
AISPIRE MD welcomes inquiries from licensed dermatologists, plastic surgeons, medical spas, and allied healthcare practices who wish to offer the line to their patients or stock it in their practice.
What We Offer Physician Accounts
- Wholesale pricing for practice stocking
- Patient education materials and take-home regimen cards
- Shelf display and practice co-branding collateral
- Clinical reference sheets suitable for patient-facing and physician-to-physician use
- Minimum order quantities available for new accounts—contact us to discuss
Ideal for Patient Recommendations in
- Post-procedure care (laser, chemical peel, microneedling, radiofrequency)
- Melasma and hyperpigmentation management
- Anti-aging and collagen maintenance programs
- Sensitive skin and rosacea-adjacent patients seeking active ingredients without irritation
- Patients seeking an evidence-based alternative to over-the-counter skincare
Physician Testimonials
Dr. Lisa Karamardian, MD
“As a practicing physician with over 30 years of experience, I hold skincare to an exceptionally high standard—and AISPIRE MD’s DNA Moisturizer has truly exceeded my expectations. The science behind this formula aligns with what I know about skin health at a cellular level, and I’ve already begun recommending it to my patients as a trusted part of their daily skincare routine. This is the kind of innovation I’ve been waiting for.”
Dr. Lisa Gorab, MD
“When I use the Salmon DNA Moisturizer, I genuinely feel it working almost instantly. can feel the peptides subtly tightening my skin while still keeping it deeply hydrated throughout the day. I truly haven’t experienced anything like this before—it delivers such powerful results while still feeling gentle on the skin.”
Contact Dr. Liu Directly
For physician-to-physician inquiries, professional account questions, or to request the clinical reference PDF, please reach out directly.
Dr. Liu welcomes peer conversations with clinicians who share a commitment to evidence-based skincare outcomes.